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The Disease Susceptibility Genetic Test-APOE CapitalBio

The main function of the APOE4 and statins is to direct the synthesis of apolipoprotein E (APOE). The main precise healthcare solutions function of APOE is to participate in the transformation and metabolism of lipoproteins, participate in the regulation of lipid metabolism in the body, and is an important internal factor affecting the level of blood lipids in the body, considered to be an important susceptibility gene for hyperlipoproteinemia and atherosclerotic vascular disease.

Due to the polymorphism of the APOE genotype, the APOE protein is also polymorphic, with three different protein isoforms: APOE4, APOE3, APOE2. Some people have only one major isomer, that is, homozygotes; some people can have two major isomers, that is, heterozygotes. It can be seen that there are six different phenotypes in the population. 

apoe4 and statins

Features of the Disease Susceptibility Genetic Test-APOE

Among lipid-lowering drugs, statins are the most important lipid-lowering drugs, and more than 60% of patients will use statins to control blood lipids. Statins are hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and are widely used for the prevention and treatment of cardiovascular disease because of their cholesterol-lowering properties. Most patients with coronary heart disease may need to take statins for life.

Studies have reported that statins have the best lipid-lowering effect on APOE 2 carriers, but less effective on APOE 4 carriers. Detection of APOE gene before taking statins can scientifically evaluate the effect of individual medication and help patients who take medication to choose drugs.

Applicable Population of the Disease Susceptibility Genetic Test-APOE

1. People with bad eating habits, such as: like eating high-fat, high-calorie, pickled, smoked, fried foods.

2. People who smoke, who have been exposed to secondhand smoke for a long time, and who drink excessively.

3. People with irregular life and rest, long-term insomnia or staying up late, and lack of exercise.

4. People with long-term mental stress, anxiety, tension, irritability.

5. Overweight, obese people.

6. People with family history of cardiovascular and cerebrovascular diseases.

7. People with dyslipidemia.

Test of the Disease Susceptibility Genetic Test-APOE

The test is based on biochip technology. By detecting two gene loci that determine APOE protein polymorphism, it evaluates its impact on the risk of cardiovascular and cerebrovascular diseases, metabolic diseases, etc., and guides the subjects to carry out effective prevention and treatment, including adjusting diet, improving lifestyle, appropriate use of drugs, strengthening physical examination, etc.

Test Content:

Apolipoprotein E-Related Disorders [10 items]Hypertension, coronary heart disease, ischemic stroke (cerebral infarction), atherosclerosis, deep vein thrombosis, Alzheimer's disease, Parkinson's disease, type 2 diabetes, diabetic nephropathy, age-related macular degeneration
Lipid-lowering drug sensitivity [7 items]Probucol, Fenofibrate, Atorvastatin, Simvastatin, Pravastatin, Fluvastatin, Rosuvastatin
Blood lipid related indicators [5 items]Apolipoprotein E, LDL cholesterol, HDL cholesterol, triglycerides, total cholesterol
The effect of diet on blood lipids [3 items]Unsaturated Fat, Cholesterol, Digestible Carbohydrates

Specification of the Disease Susceptibility Genetic Test-APOE

Sample typesVenous blood / Oral swab
TAT9 working days

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