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HLA Typing

The HLA (human leucocyte antigen) system encodes the major histocompatibility complex (MHC) proteins in humans, is closely related to the body's immune system. The HLA gene complex is located on a 3.6 Mb region within chromosome 6p21. They are the most polymorphic gene family found in the human genome, with more than 10,000 different HLA alleles reported to date, thus the capacity to mount an immune response can be remarkably different between individuals within a cohort selected from a single population.

HLA genes have been strongly implicated in transplant rejection, autoimmune disease, vaccine pharmacogenomics, cancer and infectious diseases. HLA genotyping is the identification of the HLA class I and class II gene polymorphisms for individuals, which is indispensable for transplant matching and disease association studies.

hla typing

HLA Typing Meaning

HLA typing refers to the process of determining the specific alleles present in an individual's human leukocyte antigen (HLA) genes. The HLA system is a group of genes located on chromosome 6 that encode proteins involved in the immune system's recognition and response to foreign substances, such as pathogens or transplanted tissues or organs.

HLA typing is performed through molecular methods, often utilizing techniques like Polymerase Chain Reaction (PCR) and DNA sequencing. These methods analyze specific regions within the HLA genes and identify the alleles present in an individual's genetic makeup.

HLA typing is important for several medical and scientific applications, including organ and tissue transplantation, hematopoietic stem cell transplantation (bone marrow transplantation), predicting disease susceptibility, understanding immune responses, forensic investigations, and population genetics studies.

Matching HLA types between a donor and recipient is crucial in transplantation to minimize the risk of rejection and improve the compatibility of transplanted tissues or organs. In disease research, certain HLA alleles are associated with an increased or decreased risk of developing certain conditions, aiding in understanding genetic factors and designing targeted treatment strategies.

Overall, HLA typing plays a vital role in various fields by providing valuable information about an individual's immune system and genetic compatibility, contributing to personalized medicine and scientific advancements.

HLA Typing Applications

ServiceTest content
HLA genotypingHigh resolution typing on HLA-A, B, C, DRB1, DQA1, DQB1, DPA1, DPB1 sites
KIR genotypingBefore hematopoietic stem cell transplantation, both the donor and patient need to do KIR genotyping
Chimeric STR detectionDetection of cell chimeric rate of donor and patient in patient before and after hematopoietic stem cell transplantation;
Detection of 23 autosomal STR loci and two sex marker loci
Personalized medication guidanceHLA-B*1502 allele is associated with serious adverse effects of antiepileptic drugs
HLA-B*5801 allele is associated with severe adverse reactions of ventilation medication
This technique can also be applied in disease susceptibility research, immunology research, population genetics research

Business Area of HLA Typing

  • China Marrow Donor Program

    The largest HLA matching laboratory in cooperation with China Marrow Donor Program, as the contractor of sample bank of the China Marrow Donor Program, nearly 2.43 million samples have been stored.

  • CordBlood Bank

    Has reached a long-term and stable strategic partnership with 5 CordBlood Banks across the country, and is the HLA testing laboratory with the most cooperative cord blood banks in China.

  • Clinical Hospital

    The joint HLA matching laboratory of CapitalBio Technology and Peking University Peoples Hospital was formally signed in August 2015. CapitalBio Technology has a strong alliance with domestic authoritative leukemia diagnosis and treatment hospitals, and will jointly build a top international HLA matching center to benefit patients.

ASHI (American Society for Histocompatibility and Immunogenetics) Certification
ASHI (American Society for Histocompatibility and Immunogenetics) Certification

ASHI is the most internationally authoritative institutions in histocompatibility, immunogenetics and transplantation. Obtaining ASHI certification means that CapitalBio's HLA typing testing capabilities have reached the international advanced level, and it can directly issue clinical trial reports that are acceptable overseas.

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