The Disease Susceptibility Genetic Test-Esophageal Cancer

Applicable Population of the Disease Susceptibility Genetic Test-Esophageal Cancer

1. Population with a family history of esophageal cancer.

2. Obese people.

3. People with chronic esophageal disease such as gastroesophageal reflux, achalasia, or esophageal diverticulum.

4. People who smoke and drink heavily, chew betel nut or shredded tobacco.

5. People with an unhealthy diet, such as: low intake of fresh vegetables, frequent consumption of pickled and rough, hot food.

Is Esophageal Cancer Hereditary?

Esophageal cancer can have both environmental and genetic factors contributing to its development. While most cases of esophageal cancer are not inherited, there are certain genetic factors that can increase the risk of developing this type of cancer. 

One of the most well-known genetic factors associated with esophageal cancer is a condition called familial esophageal cancer. It is a rare inherited condition in which multiple family members are affected by esophageal cancer. This condition has been associated with specific genetic mutations, such as mutations in genes like TP53 and CDH1. Individuals with familial esophageal cancer have a higher risk of developing the disease than the general population.

Apart from familial esophageal cancer, there are other genetic predispositions that can contribute to an increased risk of esophageal cancer. For example, certain genetic variants related to alcohol metabolism (such as ADH and ALDH genes) may impact the risk of developing esophageal cancer in individuals who consume alcohol excessively.

However, it's important to note that the majority of esophageal cancer cases occur sporadically, without a clear hereditary link. Environmental factors such as tobacco and alcohol use, obesity, gastroesophageal reflux disease (GERD), and exposure to certain chemicals and substances (like asbestos) play a significant role in the development of esophageal cancer.

If you have concerns about your risk for esophageal cancer or a family history of the disease, it's best to consult a healthcare professional or a genetic counselor who can provide personalized guidance based on your specific situation and family history.