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Breast Cancer Prognosis Assessment CapitalBio

This test uses RT-qPCR technology to detect the expression of 16 tumor-related genes (proliferation, invasion, HER2, and hormone-related genes) and 5 reference genes and quantifies the test results as a Recurrence Score (RS) to predict 10-year long-term recurrence risk and chemotherapy benefit. This test can aid in the development of breast cancer treatment plans and avoid conditions such as undertreatment or overtreatment.

breast cancer prognosis assessment

Features of Breast Cancer Prognosis Assessment

Genes covered by this test

ProliferationKi67, SKT15, Survivin, CCNB1(cyclin B1), MYBL2
EstrogenER, PGR, BCL2, SCUBE2
InvasionMMP11(stromolysin 3), CTSL2(cathepsin L2)
ReferenceACTB(β-actin), GAPDH, RPLPO, GUS, TFRC
OthersGSTM1, CD68, BAG1

Applicable Population of Breast Cancer Prognosis Assessment

  • Newly diagnosed breast cancer patients with stage I or II, estrogen receptor positive, lymph node metastasis negative, and to be treated with tamoxifen.

  • Menopausal patients with lymph node-positive, estrogen receptor-positive invasive breast cancer.

Specification of Breast Cancer Prognosis Assessment

Sample Types


Fresh tissue

Surgical tissue

Tissue>50mg, tumor content>30%, necrotic cells<10%

Needle biopsy tissue

1-2 strips

Length> 5mm, diameter 1-2mm

Tumor content> 30%, necrotic cells < 10%

Paraffin specimen

Paraffin section

>10 surgical slices or >15 needle biopsy slices

Area > 10mm×10mm, thickness 5-10μm

Tumor content > 30%, necrotic cells < 10%

Best within half a year, no more than 1 year

HE stained sections or pathological results are required

Paraffin block

Thickness of tissue-containing paraffin blocks > 100 μm

Tissue surface area > 25mm2

Tumor content > 30%, necrotic cells < 10%

Samples kept for less than 1 year

The Importance of Regular Follow-ups in Breast Cancer Prognosis

CapitalBio Technology, a leading company in the field of medical technology, emphasizes the importance of regular follow-ups in breast cancer prognosis. Here are some key points to consider:

  1. Early Detection of Recurrence: Regular follow-ups allow for the early detection of any recurrence or metastasis of breast cancer. This early detection can significantly improve the prognosis and provide more treatment options.

  2. Monitoring Treatment Response: Follow-ups are crucial in monitoring the patient’s response to treatment. Through prognosis assessment, doctors can determine if the treatment is working or if adjustments need to be made.

  3. Patient Support and Guidance: Regular follow-ups provide an opportunity for patients to discuss any concerns or side effects they may be experiencing. This ongoing communication can help patients feel more supported and informed about their prognosis.

  4. Updating Prognosis: Breast cancer prognosis can change over time. Regular follow-ups allow for the prognosis to be updated based on the latest test results and the patient’s overall health status.

  5. Promoting Healthy Lifestyle: Follow-ups also provide an opportunity to reinforce the importance of a healthy lifestyle in improving breast cancer prognosis. This includes regular exercise, a balanced diet, and avoiding risk factors like smoking.

  6. Psychological Well-being: Regular follow-ups can also help monitor and address the psychological impact of a breast cancer diagnosis and treatment, which can significantly affect a patient’s prognosis.

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