The system enables rapid and precise “sample in, result out” automatic and totally enclosed detection of the SARS-CoV-2. Functions such as sample lysis, nucleic acid extraction, nested amplification, and fluorescence detection are all integrated into a single microfluidic chip using a specialized fabrication method. The quick detection of SARS-CoV-2 nucleic acid is made possible by the fact that each chip can detect two samples and the entire experiment can be finished in one step within 45 mins.